Explores the biochemical, physiological, and environmental aspects of toxicology. This edition includes changes in thinking about cancer and carcinogenesis as well as the expansion of toxicogenomics. The book also includes new chapters on topics such as radiation, food safety, and natural toxins. Chapters combine background material in the appropriate discipline with new information on toxicology to stress key principles and concepts. Also included is a selection of case studies through which principles and concepts are applied to real-world issues. The book also includes an appendix of selected toxicants that describes chemical structure, category of use, and toxicity.

Chapters include:

• Measuring Toxicity and Assessing Risk 
• Toxicokinetics 
• Biotransformation 
• Cellular Sites of Action 
• Genomics and New Genetics in Toxicology 
• Carcinogenesis 
• Reproductive Toxicology and Teratology 
• Respiratory Toxicology 
• Cardiovascular Toxicology 
• Neurotoxicology 
• Hepatic Toxicology 
• Renal Toxicology 
• Immunotoxicology 
• Ecological Toxicology 
• Applications: Pharmacology and Toxicology 
• Applications: Forensic Toxicology 
• Applications: Environmental Toxicology and Pollution 
• Applications: Radiation 
• Applications: Food Safety 
• Applications: Toxins 
• Appendix: List of Selected Toxicants