Each year, HSE publishes the latest compendium set of national statistics on health and safety at work. The various statistics within the 2021 publication have to a greater or lesser extent been impacted by the Coronavirus pandemic. While every endeavour has been made during the pandemic to collect and update data on as complete and comparable basis as possible, important differences with earlier years’ data remain. This report considers the different impacts of the pandemic on health and safety statistics and the approaches taken to ensure that data quality is maintained.